Diaminothiazoles and their use for inhibiting protein kinases

Details Diaminothiazoles and their use for inhibiting protein kinases Diaminothiazoles and their use for inhibiting protein kinases

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61P 35/00 (2006.01) C07D 277/38 (2006.01) C07D 277/62 (2006.01) C07D 417/14 (2006.01) C07F 9/6539 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2371158

Diaminothiazole compounds of formula (I) that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

L'invention porte sur des composés de diaminothiazole de formule (I) modulant et/ou inhibant l'activité de certaines protéines kinases. Lesdits composés et les compositions pharmaceutiques les contenant sont capables de médier la transduction des signaux de la tyrosine kinase afin de moduler et/ou inhiber la prolifération non souhaitée des cellules. L'invention porte également sur les utilisations thérapeutiques ou prophylactiques de compositions pharmaceutiques contenant lesdits composés, et sur des procédés de traitement du cancer et d'autres états morbides associés à une angiogenèse et/ou à une prolifération des cellules, tels que par exemple la rétinopathie diabétique, le glaucome néovasculaire, la polyarthrite rhumatoïde et le psoriasis, par administration de doses efficaces desdits composés.

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