Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists

Details Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2180014

Compounds having formula (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, ant- allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

Les composés de formule (I) sont des antagonistes des effets des leucotriènes et sont utilisés comme agents anti-asthmatiques, anti-allergiques, anti-inflammatoires et cytoprotecteurs. Ils sont également utiles pour le traitement de l'angine de poitrine, des spasmes cérébraux, de la glomérulonéphrite, de l'hépatite, de l'endotoxémie, de l'uvéite et du rejet d'allogreffe.

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