Diaryl and arylheteroaryl urea derivatives as modulators of...

A - Human Necessities – 61 – K

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A61K 31/415 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2594563

The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5- HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the prophylaxis or treatment of progressive multifocal leukoencephalopathy.

La présente invention concerne certains dérivés de pyrazole de formule (I) et des compositions pharmaceutiques de ces dérivés modulant l'activité du récepteur de la sérotonine 5-HT2A. Ces composés et leurs compositions pharmaceutiques sont destinés à des méthodes utiles dans la prévention ou le traitement de la leucoencéphalopathie multifocale progressive.

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