Diaryl compounds as monoamine reuptake inhibitors

Details Diaryl compounds as monoamine reuptake inhibitors Diaryl compounds as monoamine reuptake inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/38 (2006.01) A61K 31/44 (2006.01) A61P 15/00 (2006.01) A61P 25/00 (2006.01) C07D 213/70 (2006.01)

Patent

CA 2495409

The invention relates to compounds of formula (I) which inhibit monoamine re- uptake. Compounds of the present invention activity as selective serotonin re- uptake inhibitors (SSRIs) and have utility therefore in a variety of therapeutic areas. Notably the compounds of the present invention are useful in the treatment or prevention of a variety of disorders, including those in which the regulation of monoamine transporter function is implicated, such as depression, attention deficit hyperactivity disorder, obsessive-compulsive disorder, post-traumatic stress disorder, substance abuse disorders and sexual dysfunction including premature ejaculation.

L'invention se rapporte à des composés représentés par la formule (I), qui inhibent le recaptage des monoamines. Les composés de la présente invention présentent une activité en tant qu'inhibiteurs sélectifs du recaptage de la sérotonine (SSRI) et s'avèrent utiles par conséquent dans plusieurs domaines thérapeutiques. Les composés de la présente invention s'avèrent notamment utiles pour le traitement ou la prévention de divers troubles, notamment des troubles dans lesquels la régulation de la fonction de transport des monoamines est impliquée, tels que la dépression, les troubles d'hyperactivité avec déficit de la tension, les névroses obsessionnelles, les syndromes de stress post-traumatique, les troubles liés à l'abus de substances psycho-actives et les dysfonctionnements sexuels tels que l'éjaculation précoce.

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