Diaryl ether cycloalkanes

Details Diaryl ether cycloalkanes Diaryl ether cycloalkanes

C - Chemistry, Metallurgy

07

C

167/228, 167/246

C07C 317/22 (2006.01) A61K 31/10 (2006.01) A61K 31/44 (2006.01) C07C 323/18 (2006.01) C07C 323/21 (2006.01) C07D 213/70 (2006.01)

Patent

CA 2019344

A B S T R A C T DIARYL ETHER CYCLOALKANES The invention concerns a diaryl ether cycloalkane of the formula I, or a pharmaceutically-acceptable salt thereof, Image wherein Ar1 is optionally substituted phenyl or naphthyl; X1 is oxy, thio, sulphinyl or sulphonyl; Ar2 is optionally substituted phenylene, or a 6-membered heterocyclene moiety containing up to three nitrogen atoms; R1 is (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; and R2 and R3 together form a (3-6C)alkylene group which defines an optionally substituted ring having 4 to 7 ring atoms. The invention also concerns processes for the manufacture of a diaryl ether cycloalkane of the formula I, or a pharmaceutically-acceptable salt thereof, and pharmaceutical compositions containing said cycloalkane. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.

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