Diaryl ureas with kinase inhibiting activity

G - Physics – 01 – N

Patent

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G01N 33/574 (2006.01)

Patent

CA 2526617

The present invention provides methods of using aryl ureas to treat diseases and conditions associated with signal transduction pathways comprising at least one of raf, VEGFR, PDGFR, p38 and/or FLT-3. The present invention also provides compositions and methods for identifying conditions and diseases which can be modulated with compounds of the present invention. These methods facilitate the selection of subjects who can be efficiently treated with compounds of the present invention. Additionally, the invention provides methods for monitoring subjects who have been administered a compound of the present invention.

La présente invention se rapporte à des procédés d'utilisation de diaryl-urées pour traiter des maladies et des états pathologiques associés à des voies de transduction de signaux comprenant au moins un des éléments que sont le gène raf, VEGFR, PDGFR, p38 et/ou FLT-3. La présente invention se rapporte également à des compositions et à des procédés permettant d'identifier des états pathologiques et des maladies qui peuvent être modulés avec les composés précités. Ces procédés facilitent la sélection de sujets qui peuvent être traités efficacement avec les composés précités. En outre, l'invention se rapporte à des procédés de surveillance de sujets auxquels il a été administré un tel composé.

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