Diarylalkyl piperidines useful as multi-drug resistant tumor...

C - Chemistry – Metallurgy – 07 – D

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C07D 211/16 (2006.01) A61K 31/445 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2152794

Diarylalkyl piperidines of formula (1) reverse drug resistance in multi-drug resistant tumors. These compounds apparently function by inhibiting a p-glycoprotein pump which becomes activated in late stage tumor development and which is inherently present in tumors from certain origins.

Pipéridines de diarylalkyle de la formule (1) qui inversent la résistance aux anticancéreux dans les tumeurs à résistance multiple aux anticancéreux. Lesdits composés fonctionnent apparemment en inhibant une pompe p-glycoprotéique qui est activée au stade avancé du développement tumoral et qui est présente de manière inhérente dans des tumeurs de certaines origines.

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