Diarylethylene metallocene derivatives, their processes of...

Details Diarylethylene metallocene derivatives, their processes of... Diarylethylene metallocene derivatives, their processes of...

C - Chemistry, Metallurgy

07

F

C07F 17/00 (2006.01) A61K 31/28 (2006.01) A61K 31/555 (2006.01)

Patent

CA 2235967

Compounds of general Formula (I), (see fig I) wherein R3, R4, R5 and Z are as specifically defined, are provided herein, as well as their processes of preparation; and pharmaceutical compositions containing them. Thesederivatives are suitable for the preparation of antitumoral drugs for use, in particular, in the treatment of estrogen-dependent cancers.

Divulgation de composés de la formule générale (I), (voir la fig. I), dans laquelle R3, R4, R5 et Z sont tels que définis spécifiquement, de même que des processus de leur préparation et de compositions pharmaceutiques à base de ces composés. Ces dérivés conviennent à la préparation de médicaments antitumoraux servant, en particulier, au traitement de cancers dépendant des oestrogènes.

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