Diarylfluoromethane compounds

Details Diarylfluoromethane compounds Diarylfluoromethane compounds

C - Chemistry, Metallurgy

07

D

C07D 249/02 (2006.01) A61K 31/395 (2006.01) C07D 209/20 (2006.01) C07D 213/26 (2006.01) C07D 213/57 (2006.01) C07D 215/12 (2006.01) C07D 217/14 (2006.01) C07D 233/61 (2006.01) C07D 237/08 (2006.01) C07D 239/26 (2006.01) C07D 241/12 (2006.01) C07D 249/04 (2006.01) C07D 257/04 (2006.01) C07D 405/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2057338

Compounds of formula I Image wherein Z is 1-imidazolyl, 1-(1,2,4-triazolyl), 1-(1,2,3- triazolyl), 1-tetrazolyl or 2-tetrazolyl; each of R1 and R2, independently of the other, is hydrogen or lower alkyl; or R1 and R2 together are 1,4-butylene or form a benzo group; R is 4-cyanophenyl or 4-bromophenyl; and X is cyano; or a salt thereof, have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.

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