C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/242.5
C07D 471/04 (2006.01)
Patent
CA 1301155
960-103.1.1 OUS DIASTEREOISOMERIC TETRAHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATIVES ABSTRACT The diastereoisomeric forms of N-(4-[2-(2- amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]- pyrimidin-6-yl)ethyl]benzoyl)-L-glutamic acid are antineoplastic agents. The compounds are prepared by separation of the diastereoisomeric form of the correspondingly protected glutamic derivatives and hydrolytic or hydrogenolytic removal of carboxylic acid and/or amino protecting groups.
537814
Beardsley George Peter
Fletcher Stephen R.
Shih Chuan
Taylor Edward C.
Gowling Lafleur Henderson Llp
The Trustees Of Princeton University
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