Diastereoselective hydrogenation of folic acid to...

Details Diastereoselective hydrogenation of folic acid to... Diastereoselective hydrogenation of folic acid to...

C - Chemistry, Metallurgy

07

D

C07D 475/04 (2006.01)

Patent

CA 2086911

O.Z. 0050/42948 Abstract of the Disclosure: A method for the diastereo- selective hydrogenation of folic acid to tetrahydrofolic acid, comprises carrying out the hydrogenation of the folic acid in the presence of an immobilized rhodium(I) complex of an optically active diphosphine in a neutral aqueous buffer solution under an H2 pressure of more than 20 bar and at a temperature exceeding 60°C.

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