C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 227/18 (2006.01) C07C 227/32 (2006.01) C07C 229/14 (2006.01) C07C 229/20 (2006.01) C07C 229/36 (2006.01)
Patent
CA 2575139
This invention describes a reductive amination process whereby perfluorinated ketones or ketals are combined with .alpha.-aminoesters under basic conditions to form metal carboxylates. Diastereoselective reductions of the metal carboxylates enable access to two diastereomers, depending on the reducing conditions.
L~invention concerne un procédé d~amination réductrice dans lequel des cétones ou des cétals perfluorés qui sont combinés avec des .alpha.-aminoesters dans des conditions basiques pour former des carboxylates de métal. Les réductions diastéréosélectives de carboxylates de métal permettent l~accès à deux disastéréomères en fonction des conditions de réduction.
Chen Cheng Yi
Devine Paul N.
Foster Bruce S.
Hughes Greg
O'shea Paul
Hughes Greg
Merck & Co. Inc.
Merck Frosst Canada Ltd.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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