Diastereoselective synthesis process for the preparation of...

Details Diastereoselective synthesis process for the preparation of... Diastereoselective synthesis process for the preparation of...

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01)

Patent

CA 2563807

A diastereoselective synthesis process for the preparation of an enantiomer of 6-~[amino(4-chlorophenyl)(1-methyl-1 H-imidazol-5-yl)methyl]-4-(3- chlorophenyl)- 1-~methyl-2(1H)-quinolinone which comprises the conversion of (.plusmn.)-6-[chloro(4~-chlomphenyl)(I-methyl-lH-imidazol-5-yl)methyl]-4-(3- chlorophenyl)-1-methyl~2(IH)-quinolinone into a compound of formula (VIII) wherein aryl is phenyl substituted once or twice with C1-6alkyloxy or naphtalenyl substituted once or twice with Cl-6alkyloxy.

L'invention concerne un procédé de synthèse diastéréosélective pour la préparation d'un énantiomère de 6-[amino(4-chlorophényl)(1-méthyl-1<I>H</I>-imidazol-5-yl)méthyl]-4-(3-chlorophényl)-1-méthyl-2(1<I>H</I>)-quinolinone qui consiste à convertir du (.plusmn.)-6-[chloro(4-chlorophényl)(I-méthyl-l<I>H</I>-imidazol-5-yl)méthyl]-4-(3-chlorophényl)-1-méthyl-2(I<I>H</I>)-quinolinone en un composé de formule générale (VIII) dans laquelle aryle est substitué par phényle une ou deux fois avec C¿1-6?alkyloxy ou est substitué par naphtalényle une fois ou deux avec C¿l?-¿6?alkyloxy.

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