Diastereoselective synthesis process with...

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C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/4178 (2006.01) C07D 233/54 (2006.01)

Patent

CA 2563806

A diastereoselective synthesis process for the preparation of (R)-(+)- 6- [amino(4~chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1- methyl~2(IH)-quinolinone which comprises the preparation of a compound of formula (XVII) : and the stereochemically isomeric forms thereof wherein R is C1-6alkyl or C1-6alkylphenyl-.

L'invention porte sur un procédé de synthèse de préparation de (R)-(+)- 6-[amino(4-chlorophényl)(1-méthyl-1H-imidazol-5-yl)méthyl]-4-(3-chlorophényl)-1-méthyl-2(IH)-quinolinone consistant à préparer un composé de formule (XVII), dans laquelle: R est C1-6 alkyle ou C1-6 alkylphényle-, puis son isomère stéréochimique.

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