Diaza- or thiazadione derivatives with neuroprotective activity

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 31/4188 (2006.01) A61K 31/427 (2006.01) C07D 277/34 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2554217

The present invention relates to certain derivatives of cycloalkanediones invariably substituted with a chroman-2-yl, 2-quinolyl or -O-phenyl residue which are serotonin (5-hydroxytryptamine, 5-HT) 5-HT1A receptor subtype agonists modulators, to their stereochemical isomers and to their use in the preparation of a medicament for the treatment of pathological states for which an agonist a modulator of these receptors is indicated.

L'invention concerne certains dérivés de cycloalcanediones invariablement substitués par un résidu chroman-2-yl, 2-quinolyle or -O-phényle, qui sont des modulateurs agonistes du sous-type (5-hydroxytryptamine, 5-HT) 5-HT¿1A? des récepteurs de la sérotonine, ainsi que leurs isomères stéréochimiques, et leur utilisation pour la préparation d'un médicament destiné au traitement d'états pathologiques pour lesquels un modulateur ou agoniste de ces récepteurs est indiqué.

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