Diaza-spiro[3,5]nonane derivatives

Details Diaza-spiro[3,5]nonane derivatives Diaza-spiro[3,5]nonane derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61K 31/435 (2006.01)

Patent

CA 2274202

The invention relates to compounds of the general formula (see formula I) wherein R1 is C6-12-cycloalkyl, optionally substituted by lower alkyl or C(O)O lower alkyl, indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; acenaphthen-1-yl; bicyclo[3.3.1]non-9-yl, octahydro-inden-2-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl, decahydro-azulen-2-yl; bicyclo[6.2.0]dec-9-yl; decahydro-naphthalen-1-yl, decahydro-naphthalen-2-yl; tetrahydro-naphthalen-1-yl, tetrahydro-naphthalen-2-yl or 2-oxo-1,2-diphenyl-ethyl; R2 is =O or hydrogen, R3 is hydrogen, isoindolyl-1,3-dione, lower alkoxy, lower alkyl, amino, benzyloxy, -CH2OR5 or -CH2N(R5)2; R4 is hydrogen or -CH2OR5; R5 is hydrogen or lower alkyl; A is cyclohexyl or phenyl, optionally substituted by lower alkyl, halogen or alkoxy; to racemic mixtures and their corresponding enantiomers and or pharmaceutically acceptable acid addition salts thereof. The compounds of the present invention are agonists and/or antagonists of the orphamin FQ(OFQ) receptor and therefore useful in the treatment of diseases, related to this receptor.

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