C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/08 (2006.01) A61K 31/551 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2554050
This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro- degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemicals substances.
L'invention concerne de nouveaux dérivés d'aryle diazabicycliques constituant des ligands cholinergiques des récepteurs d'acétylcholine nicotinique et des modulateurs des récepteurs et des transporteurs de monoamine. En raison de leur profil pharmacologique, les composés de l'invention peuvent être utilisés dans le traitement de maladies ou de troubles aussi divers que ceux associés au système cholinergique du système nerveux central (CNS), ou au système nerveux périphérique (PNS), les maladies ou les troubles associés à la contraction des muscles mous, les maladies ou les troubles endocriniens, les maladies ou les troubles associés à la neurodégénération, les maladies ou les troubles associés à l'inflammation, la douleur, et les symptômes de sevrage causés par la fin de l'abus de substances chimiques.
Jorgensen Tino Dyhring
Nielsen Elsebet Ostergaard
Olsen Gunnar M.
Peters Dan
Timmermann Daniel B.
Mccarthy Tetrault Llp
Neurosearch A/s
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