C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/08 (2006.01) A61K 31/4995 (2006.01) A61K 31/551 (2006.01) A61P 25/00 (2006.01) C07D 471/08 (2006.01)
Patent
CA 2555311
This invention relates to novel diazabicyclic aryl derivatives represented by Formula (I); which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
L'invention concerne de nouveaux dérivés d'aryle diazabicycliques représentés par la formule (I), constituant des ligands cholinergiques des récepteurs d'acétylcholine nicotinique. En raison de leur profil pharmacologique, les composés de l'invention peuvent être utilisés dans le traitement de maladies ou de troubles aussi divers que ceux associés au système cholinergique du système nerveux central (CNS), ou au système nerveux périphérique (PNS), les maladies ou les troubles associés à la contraction des muscles mous, les maladies ou les troubles endocriniens, les maladies ou les troubles associés à la neurodégénération, les maladies ou les troubles associés à l'inflammation, la douleur, et les symptômes de sevrage causés par la fin de l'abus de substances chimiques.
Ahring Philip K.
Jorgensen Tino Dyhring
Olsen Gunnar M.
Ostergaard Nielsen Elsebet
Peters Dan
Mccarthy Tetrault Llp
Neurosearch A/s
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