C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/08 (2006.01) A61K 31/5513 (2006.01) A61K 31/5517 (2006.01) A61P 25/18 (2006.01) C07D 213/30 (2006.01) C07D 243/14 (2006.01) C07D 487/08 (2006.01) C07D 519/00 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2370411
The present invention relates to novel compounds that are CNS-penetrant alpha-7 nicotinic receptor agonists of the general formula I: Image wherein m, n and o are integers from 1-2; X and Y are O, S or NR1 (wherein R1 is H, optionally substituted alkyl, an ester, an aldehyde, a ketone, optionally substituted carbamoyl, or an optionally substituted sulfamoyl); and Q is~ optionally substituted alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, bicycloalkyl, bicycloalkenyl, heterobicycloalkyl, heterobicycloalkenyl, aryl or heteroaryl. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant alpha-7 nicotinic receptor agonist for treating disorders of the central nervous system (CNS) and other disorders in a mammal, including a human.
O'donnell Christopher John
O'neill Brian Thomas
Pfizer Products Inc.
Smart & Biggar
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