Diazepan derivatives modulators of chemokine receptors

Details Diazepan derivatives modulators of chemokine receptors Diazepan derivatives modulators of chemokine receptors

C - Chemistry, Metallurgy

07

D

C07D 243/14 (2006.01) A61K 31/551 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 471/10 (2006.01)

Patent

CA 2649636

The invention is concerned with novel diazepan derivatives of formula (I) wherein A, X, R3, R4, R5, R6, R8, R9, R10, R11, R12, R13, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor, CCR-5 receptor and/or CCR-3 receptor and can be used as medicaments.

L'invention porte sur de nouveaux dérivés du diazépan de formule (I) dans laquelle: A, X, R3, R4, R5, R6, R8, R9, R10, R11, R12, R13, m et n sont tels que définis dans la description et dans les revendications, et sur leurs sels physiologiquement acceptables. <ces composés sont des antagonistes des récepteurs CCR-2, CCR-5 et/ou CCR-3 et peuvent être utilisés comme médicaments.

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