Diazepan derivatives or salts thereof

Details Diazepan derivatives or salts thereof Diazepan derivatives or salts thereof

C - Chemistry, Metallurgy

07

D

C07D 243/08 (2006.01) A61K 31/551 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 471/04 (2006.01) A61K 7/02 (2000.01)

Patent

CA 2395846

Compounds exhibiting a blood-anticoagulant effect on the basis of the inhibition of activated blood coagulation factor X and being useful as blood anticoagulants or preventive or therapeutic drugs for diseases caused by thrombus or embolus. As the active ingredient of these drugs are used diazepane derivatives such as 4- [(3-carbamidoylphenylamino)methyl]-3-[4-(4-methyl- 1,4-diazepan-1-yl)benzoylamino]benzoic acid and 3-hydroxy-4'-methoxy-2-{[4-(4- methyl-1,4-diazepan-1-yl)benzoyl]amino}benzanilide or salts of these derivatives.

L'invention concerne des composés présentant une activité anticoagulante sur la base de l'inhibition du facteur X de coagulation sanguine activé. Ces composés sont utiles en tant que médicaments anticoagulants, préventifs ou thérapeutiques destinés aux maladies provoquées par un thrombus ou un embole. En tant qu'ingrédient actif de ces médicaments, on utilise des dérivés de diazépane tels que l'acide 4-[(3-carbamidoylphénylamino)méthyl]-3-[4-(4-méthyl-1,4-diazépan-1-yl)benzoylamino]benzoïque et le 3-hydroxy-4'-méthoxy-2-{[4-(4-méthyl-1,4-diazépan-1-yl)benzoyl]amino}benzanilide ou des sels de ces dérivés.

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