C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01) A61K 31/55 (2006.01) A61P 3/04 (2006.01) A61P 25/00 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 417/04 (2006.01)
Patent
CA 2647678
The present invention is directed to diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
La présente invention concerne des composés diazépane qui sont des antagonistes des récepteurs de l'orexine et qui sont utiles dans le traitement ou la prévention de troubles et de maladies neurologiques et psychiatriques dans lesquels les récepteurs de l'orexine sont impliqués. L'invention concerne également des compositions pharmaceutiques renfermant ces composés ainsi que l'utilisation de ces composés et de ces compositions dans la prévention ou le traitement de maladies dans lesquelles les récepteurs de l'orexine sont impliqués.
Brashear Karen M.
Coleman Paul J.
Cox Christopher D.
Smith Anthony M.
Whitman David B.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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