C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 243/08 (2006.01) A61K 31/551 (2006.01) A61P 3/00 (2006.01)
Patent
CA 2668504
The present invention relates to diazepane-acetamide derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11 .beta.-HSD-1 ) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
La présente invention concerne des dérivés de diazépane-acétamide de formule I en tant qu'inhibiteurs sélectifs de l'enzyme 11-bêta-hydroxystéroïde déshydrogénase de type 1 (11 .beta.-HSD-1) et l'utilisation de tels composés pour le traitement et la prévention du syndrome métabolique, du diabète, de la résistance à l'insuline, de l'obésité, des troubles lipidiques, du glaucome, de l'ostéoporose, des troubles cognitifs, de l'anxiété, de la dépression, des troubles immunitaires, de l'hypertension et d'autres maladies et troubles.
Carniato Denis
Charon Christine
Doare Liliane
Leriche Caroline
Roche Didier
Fetherstonhaugh & Co.
Merck Patent Gmbh
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