Diazepine derivatives

Details Diazepine derivatives Diazepine derivatives

C - Chemistry, Metallurgy

07

D

C07D 495/14 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2110529

ABSTRACT The compounds of the formula Image I wherein R1 is -OR6 or -NHR7 in which R6 and R7, which may be the same or different, are hydrogen, lower alkyl, lower alkenyl, cycloalkyl or phenyl, R2 is lower alkyl, lower alkoxy or trifluoromethyl, R3 and R4, independently, are hydrogen, chlorine, fluorine, lower alkyl or lower alkoxy and R5 is lower alkyl or cycloalkyl and, when one or more asymetric carbon is present, their enantiomers, diastereomers and racemates and pharmaceutically acceptable salts thereof, are useful as bronchopulmonary agents, for example, in the relief of asthma and allergic reactions. They can be prepared according to known methods.

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