Diazepino-indoles as phosphodiesterase iv inhibitors

C - Chemistry – Metallurgy – 07 – D

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C07D 487/06 (2006.01) A61K 31/55 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2220407

Diazepino-indoles of formula (I), wherein A is mono- to trisubstituted aryl or heteroaryl, and B is an -OR1 or -NR2R3 group where R1, R2 and R3 are particularly hydrogen, and racemic forms, enantiomers and pharmaceutically acceptable salts thereof, as phosphodiesterase IV inhibitors, are disclosed.

Diazépino-indoles de formule (I) dans laquelle A est aryle ou hétéroaryle mono- à trisubstitué, B est un groupe -OR1 ou -NR2R3, où R1, R2, R3 sont notamment hydrogènes, leurs formes racémiques, leurs énantiomères, et leurs sels pharmaceutiquement acceptables; qui sont inhibiteurs de phosphodiestérases 4.

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