Diazepinones

Details Diazepinones Diazepinones

C - Chemistry, Metallurgy

07

D

167/210, 260/239

C07D 471/04 (2006.01) A61K 31/55 (2006.01)

Patent

CA 1269374

Abstract Diazepinones Compounds of formula I are described, (I) Image wherein X represents the group -?HR, -?R or an oxygen atom and A represents the groups -NR1R2, wherein R1 and R2 represent hydrogen atoms or alkyl, cycloalkyl or phenylalkyl groups, n represents the number 0, 1 or 2, R3 represents a hydrogen atom, a hydroxy or alkyl group or a group -(CH2)n- N-R5R6 (R5 and R6 being lower alkyl groups) and R4 is an alkyl or phenylalkyl group. The compounds and their salts have favorable effects on heart rate and can be used as vagal pacemakers for treating bradycardia and bradyarrhythmia in human and veterinary medicine. Some of these compounds also have very good antithrombotic effects.

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