Diazine derivatives

Details Diazine derivatives Diazine derivatives

C - Chemistry, Metallurgy

07

D

167/208, 260/262

C07D 401/04 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07D 239/48 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01) C07D 491/10 (2006.01) C07D 491/113 (2006.01)

Patent

CA 2032743

ABSTRACT DIAMINE DERIVATIVES This invention concerns compounds of the formula I: Image Image wherein R1 is (1-10C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-4C)- alkyl, phenyl or phenyl(1-4C)alkyl, the phenyl moiety of the latter two optionally bearing one or more substituents; R2 is hydrogen, (1-4C)alkyl, amino or (1-4C)alkylamino; R6 is (1-4C)alkyl, amino or (1-4C)alkylamino; Q is a group of formula II, in which case R3 and R4 are independently hydrogen, (1-4C)alkyl, phenyl or benzyl the phenyl moiety of the latter two optionally bearing one or two substituents; R5 is hydrogen, (1-4C)alkyl or (2-4C)alkenyl; A and B are independently ethylene or trimethylene; Z is a direct bond between A and B, or an oxy, thio, carbonyl, methylene, ethylenedioxymethylene, ethylidene, or isopropylidene link, or Z is a group of the formula =N.M in which M is hydrogen, (1-6C)alkyl, phenyl or benzyl, the phenyl moiety of the latter two optionally bearing one or two substituents; or Q represents a saturated 9- or 10-membered bicyclic amino group, which is unsubstituted or is substituted by one or two substituents; and Y is a physiologically acceptable anion. The invention also includes certain closely related anhydro-base derivatives which, like the compounds of formula I, possess beneficial effects on the cardiovascular system (and in particular beneficial effects modulated via the sino-atrial node). Also included are pharmacuetical compositions containing compounds of formula I (or a related anhydro-base) as active ingredient, and processes for the manufacture of the various novel compounds

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