Diazine-ethenyl-phenyl oxamic acids and esters and salts...

Details Diazine-ethenyl-phenyl oxamic acids and esters and salts... Diazine-ethenyl-phenyl oxamic acids and esters and salts...

C - Chemistry, Metallurgy

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C07D 237/06 (2006.01) C07D 237/08 (2006.01) C07D 237/12 (2006.01) C07D 239/24 (2006.01) C07D 239/26 (2006.01) C07D 239/42 (2006.01) C07D 239/52 (2006.01) C07D 241/10 (2006.01) C07D 241/12 (2006.01) C07D 241/16 (2006.01)

Patent

CA 1219873

OXAMIC ACID DERIVATIVES ABSTRACT Compounds of the formula I Image (I) (wherein R1 is hydrogen or alkyl of 1 to 4 carbon atoms; R2 is hydrogen, methyl, hydroxyl, alkoxy of 1 to 4 carbon atoms, di(alkyl of 1 to 2 carbon atoms)amino-(alkoxy of 1 to 4 carbon atoms) or -HN-CO-CO-OR1; and A is Image [wherein R3 is hydrogen, methyl, alkoxy of 1 to 4 carbon atoms, hydroxyl, amino, alkanoyloxy of 1 to 2 carbon atoms, di(alkyl of 1 to 2 carbon atoms)-amino-(alkoxy of 1 to 4 carbon atoms) or acetamido; and R4 is hydrogen, amino, alkoxy of 1 to 4 carbon atoms, halogen or -HN-CO-CO-OR1]) and salts thereof. The compounds as well as the physiologically acceptable salts are useful for the treatment of immunological, inflammatory and allergic disorders such as allergic asthma, rhinitis, conjunctivitis, hay fever, urticaria, food allergies and the like.

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