Diazonium salts and reagents for bilirubin assay

G - Physics – 01 – N

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260/179, 150/9

G01N 33/72 (2006.01) C07C 113/04 (1985.01) C07C 143/80 (1985.01)

Patent

CA 1192902

Abstract Diazonium salts which are useful in an assay for bilirubin are disclosed. The salts have the structural formula: Image wherein X- is a stabllizing anion, Y is CO- or SO2-; and R1 and R2 are independently selected from hydrogen, alkyl, aryl, carboxyalkyl and hydroxyalkyl providing R1 and R2 are not both hydrogen; R3 and R4 are independently selected from groups such that the sum of the Hammett sigma values for R3 and R4 does not exceed +0.4 or R3 and R4 represent the carbon atoms necessary to com- plete a fused carbocyclic ring structure.

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