Dibenz (b,f) oxepin and dibenzo (b,f) thiepin derivatives...

Details Dibenz (b,f) oxepin and dibenzo (b,f) thiepin derivatives... Dibenz (b,f) oxepin and dibenzo (b,f) thiepin derivatives...

C - Chemistry, Metallurgy

07

D

260/355.5, 260/3

C07D 337/02 (2006.01) C07C 41/26 (2006.01) C07C 43/295 (2006.01) C07C 59/68 (2006.01) C07C 65/34 (2006.01) C07D 295/194 (2006.01) C07D 313/04 (2006.01) C07D 313/14 (2006.01) C07D 337/14 (2006.01)

Patent

CA 1126739

ABSTRACT OF THE DISCLOSURE Novel dibenz[b,f]oxepin and dibenzo[b,f]thiepin derivatives of the formula Image wherein X is an oxygen or sulfur atom, each of R1 and R2 is a hydrogen atom or a methyl group, and R3 is a hydrogen atom or a 2-(2-hydroxyethoxy)ethyl group; provided that when R1 is a hydrogen atom, the group Image is a group other than a l-carboxyethyl group; and when X is a sul- fur atom, both R1 and R2 are methyl groups; and pharmaceutically acceptable salts of said compounds in which R3 is a hydrogen atom. Compositions of said compounds, processes for the preparation of said compounds, and a method of using said compounds are also provided. These novel compounds have excellent anti-inflammatory, analgestic and antipyretic activities.

321833

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