Dibenz¬be|oxepinacetic acid derivatives, the preparation...

C - Chemistry – Metallurgy – 07 – D

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C07D 313/12 (2006.01) A61K 31/335 (2006.01)

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CA 1243326

-20- ABSTRACT DIBENZ[be]OXEPINACETIC ACID DERIVATIVES THE PREPARATION THEREOF AND THEIR APPLICATION IN THERAPY Compounds of general formula Image in which R1, taken separately, denotes a hydrogen atom or a C1-C4 alkyl group, and R2, taken separately, denotes a hydrogen atom, a C1-C4 alkyl group or a phenylthio or phenylsulphonyl group, or alternatively R1 and R2 together form an ethano bridge or, together with the two carbon atoms 8 and 9, form a fused benzene ring, R3 denotes a hydrogen atom or a methyl group and R4 denotes a hydrogen atom, a C1-C4 alkyl group or a cation of a base which is acceptable in pharmacology, the group CH(R3)COOR4 being at position 2 or 3. have uses in treatment of inflammation, pain and undesirable platelet aggregation.

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