Dibenz-oxepin and -thiepin derivatives

Details Dibenz-oxepin and -thiepin derivatives Dibenz-oxepin and -thiepin derivatives

C - Chemistry, Metallurgy

07

D

167/207, 260/353

C07D 313/12 (2006.01) C07D 337/12 (2006.01) C07D 405/06 (2006.01)

Patent

CA 1309409

ABSTRACT The invention concerns: Novel dibenz/b,e/oxepin and dibenz/b,e/thiepin compounds having the general formula: (I) Image wherein X is O or S, R1, R2, R3 and R4 are the same or different and are each selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower. alkynyl, lower cycloalkyl, lower alkoxy, lower alkylthio, lower alkyl- sulphinyl, lower alkylsulphonyl, halogen, trifluoromethyl, trifluoro- methylthio, lower dialkylsulphonamido, nitro, hydroxy, cyano, carbamyl, carboxy, lower alkoxycarbonyl, amino, N-lower alkylamino, N,N-dilower- alkylamino, lower acylamido, lower alkanesulfonamido and lower acyl and, when on adjacent carbon atoms at the positions 2 and 3 and/or 8 and 9, two of the substituents R1 and R2 or R3 and R4 taken together may form a methylenedioxy group; R5 and R6 are the same or different and are selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, aralkyl, lower hydroxyalkyl, lower aminoalkyl, lower alkyl- aminoalkyl, lower dialkylaminoalkyl, lower alkoxyalkyl and together with the nitrogen atom, R5 and R6 may form a 5- or 6-membered ring, such as pyrrolidine, piperidine, morpholine, piperazine, and N-lower alkyl or N-hydroxy lower alkyl substituted rings such as N-alkylpiperazine or N- hydroxyalkyl piperazine or the like, R7 is hydrogen or lower alkyl; optionally in the form of addition salts with pharmaceutically accept- able inorganic or organic acids and optionally in the form of essential- ly pure enantiomers. The invention also includes compositions containing the novel compounds, processes for their preparation and a method of treatment therewith. The compounds have pharmacological effects and are useful in the treat- ment of urinary disorders by increasing the ability to control urination,

500044

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