Dibenzo [a,d] cycloheptene derivatives and process for...

Details Dibenzo [a,d] cycloheptene derivatives and process for... Dibenzo [a,d] cycloheptene derivatives and process for...

C - Chemistry, Metallurgy

07

C

260/202.8

C07C 59/40 (2006.01) C07C 69/73 (2006.01)

Patent

CA 1159826

ABSTRACT OF THE DISCLOSURE Novel compounds, dibenzo[a,d]cycloheptene derivatives, of the general formula Image I wherein Rl represents a hydrogen atom, a halogen atom or a lower alkyl group, R2 and R3 each represent a hydrogen atom or a lower alkyl group, and Z represents a group of the formula -?=CH- or -?-CH2-. These novel compounds are useful as non-steroidal anti-inflammatory agents free from gastrointestinal lesions. The compounds of formula I can be prepared, for example, by cyclizing a compound of the general formula Image II wherein Rl and R2 are as defined above, X represents a hydroxyl group or a halogen atom, one Y represents a group of the formula -CH2COX and the other Y represents a hydrogen atom; optionally hydrolyzing the cyclized product; and optionally esterifying the product, and/or etherifying its enol group.

361591

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