Dibenzo[b,e]oxepine derivatives, process for producing them...

C - Chemistry – Metallurgy – 07 – D

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C07D 493/04 (2006.01) A61K 31/35 (2006.01) C07D 313/12 (2006.01)

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CA 2175070

Compounds of formula (I), in which Q is hydrogen, a hydroxy group or a C1 to C8 alkoxy group, which may, if desired, be substituted with carboxyl or C1 to C6 alkoxy carbonyl and either Y and Z together form a (a) group and X is hydrogen, C1 to C6 alkyl or C2 to C6 alkenyl or Y and X together form a (b) group or an alkylene radical of 2-4 carbon atoms and Z is hydrogen, C1 to C6 alkyl or C1 to C6 alkanoyl, where R is hydrogen or a C1 to C6 alkyl radical, and their physiologically tolerable salts, process for producing them and medicaments containing these compounds for the treatment of inflammatory and allergic diseases.

Composés de formule (I) dans laquelle: Q désigne l'hydrogène, un groupe hydroxy ou un groupe alcoxy C¿1? à C¿8?, pouvant être remplacé le cas échéant par un carboxyle ou un alcoxycarbonyle C¿1? à C¿6? et dans laquelle soit Y et Z forment ensemble un groupe (a) et X désigne l'hydrogène, un alkyle C¿1? à C¿6? ou un alkényle C¿2? à C¿6?, soit Y et X forment ensemble un groupe (b) ou un reste alkylène de 2 à 4 atomes de carbone et Z désigne l'hydrogène, un alkyle C¿1? à C¿6? ou un alcanyle C¿1? à C¿6?, et R désigne l'hydrogène ou un reste alkyle C¿1? à C¿6?, ainsi que leurs sels physiologiquement tolérables, des procédés pour leur préparation et des médicaments contenant ces composés pour le traitement de maladies inflammatoires et allergiques.

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