C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 407/04 (2006.01) A61K 31/35 (2006.01) C07D 311/80 (2006.01)
Patent
CA 2438713
Molecules demonstrating anti-proliferative effects against epithelial cancer cell lines and endothelial cells and methods of synthesis are disclosed. The molecules are intended for use in therapeutic preparations for the treatment of cancer through either anti-angiogenesis or other anti-cancer mechanisms. The compounds specified are 6H-dibenzo[b,d]pyran-6-one derivatives and have been shown to be antiproliferative against human endothelial cells.
L'invention porte sur des molécules ayant démontré un effet antiprolifératif sur des lignées de cellules épithéliales et endothéliales cancéreuses, et sur leur procédé de synthèse. Lesdites molécules sont prévues pour être utilisées dans des préparations thérapeutiques de traitement du cancer par l'intermédiaire de mécanismes d'anti-angiogenèse ou d'autres mécanismes anticancéreux. Lesdits composants, des dérivés du 6H-dibenzo[b,d]pyran-6-one, ont démontré une action antiproliférative sur les cellules endothéliales humaines.
Lazarowych Natalie
Mercure Julie
Redden Peter
Schmidt Jonathan Martin
Whelan John
Nanodesign Inc.
Paloma Pharmaceuticals Inc.
Ridout & Maybee Llp
LandOfFree
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