Dibenzoazepine and dibenzooxazepine trpa1 agonists

Details Dibenzoazepine and dibenzooxazepine trpa1 agonists Dibenzoazepine and dibenzooxazepine trpa1 agonists

C - Chemistry, Metallurgy

07

D

C07D 223/20 (2006.01) A61K 31/55 (2006.01) A61K 31/553 (2006.01) C07D 267/20 (2006.01)

Patent

CA 2706903

The present invention is related to novel tricyclic compounds of formula (I) having TRPA1 receptor agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use as pharmacological tools, or as irritant incapacitants, or in the treatment of diseases linked to the modulation of the TRPA1 receptors in animals, in particular humans.

La présente invention porte sur de nouveaux composés tricycliques représentés par la formule (I) ayant des propriétés agonistes des récepteurs TRPA1, sur des compositions pharmaceutiques comprenant ces composés, sur des procédés chimiques pour préparer ces composés et sur leur utilisation comme outils pharmacologiques, ou comme inhibiteurs d'irritants, ou dans le traitement de maladies liées à la modulation des récepteurs TRPA1 chez les animaux, en particulier les êtres humains.

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