Dibenzodiazepinone analogues, processes for their production...

Details Dibenzodiazepinone analogues, processes for their production... Dibenzodiazepinone analogues, processes for their production...

C - Chemistry, Metallurgy

07

D

C07D 243/38 (2006.01) A61K 31/5513 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2581658

The invention relates to biologically active dibenzodiazepinone analogues represented by Formula (I) where R1 is a linear C1-10 alkyl and the farnesyl moiety can have one, two or three hydrogenated or hydroalkoxylated double bonds), or a pharmaceutically acceptable salt or prodrug thereof, to pharmaceutical compositions comprising these compounds, methods of producing them, and their use in the preparation of medicaments for the treatment of neoplastic conditions.

L'invention concerne des analogues de dibenzodiazépinone biologiquement actifs représentés par la formule (I) dans laquelle R1 représente un C1-10 alkyle linéaire et la fraction farnésyle peut comprendre une, deux ou trois liaison(s) double(s) hydrogénée(s) ou hydroalkoxylée(s). L'invention concerne également un sel pharmaceutiquement acceptable de ces analogues ou un promédicament de ce sel, des compositions pharmaceutiques comprenant lesdits composés, leurs procédés de production et leur utilisation pour préparer des médicaments permettant de traiter des états néoplasiques.

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