Dibenzodioxazecine and dibenzodioxaazacycloundecine derivatives

C - Chemistry – Metallurgy – 07 – D

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167/209, 260/237

C07D 273/01 (2006.01) A61K 31/395 (2006.01) C07D 273/00 (2006.01)

Patent

CA 2027838

ABSTRACT Dibenzodioxazecine and dibenzodioxaazacycloundecine derivatives having the general formula I: Image I or a pharmaceutically acceptable salt or nitrogen oxide thereof, in which R1, R2, R3 and R4 each represent independently hydrogen, hydroxy, halogen, cyano, alkyl, alkoxy or CF3; R5 represents hydrogen, alkyl, alkenyl, aralkyl, hydroxyalkyl or acyloxyalkyl; and n represents the number 1 or 2. The compounds in accordance with the invention are valuable C.N.S. (central nervous systems) active compounds, and in particular possess strong anti- psychotic properties with low propensity to induce extra-pyramidal side effects.

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