Dibenzofuran derivatives as inhibitors of pde-4 and pde-10

Details Dibenzofuran derivatives as inhibitors of pde-4 and pde-10 Dibenzofuran derivatives as inhibitors of pde-4 and pde-10

C - Chemistry, Metallurgy

07

D

C07D 307/91 (2006.01) A61K 31/335 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61P 29/00 (2006.01) C07D 405/04 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2663178

The present invention relates to novel heterocyclic compounds that are useful as phosphodiesterase inhibitors (PDEs) in particular phosphodiesterase type 4 (PDE IV) inhibitors and phosphodiesterase type 10 (PDE 10) inhibitors, processes for their preparation, pharmaceutical compositions containing them and their use in treating allergic and inflammatory diseases as well as for inhibiting the production of Tumor Necrosis Factor(TNF-.alpha.).

L'invention concerne de nouveaux composés hétérocycliques utiles en tant qu'inhibiteurs de phosphodiestérase (PDEs), en particulier des inhibiteurs de phosphodiestérase de type 4 (PDE IV) et des inhibiteurs de phosphodiestérase de type 10 (PDE 10), des procédés servant à les préparer, des compositions pharmaceutiques les contenant et leur utilisation pour le traitement de maladies allergiques et inflammatoires, ainsi que pour inhiber la production du facteur de nécrose tumorale (TNF-.alpha.).

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