Dibenzonaphthyridine derivatives and methods of use thereof

Details Dibenzonaphthyridine derivatives and methods of use thereof Dibenzonaphthyridine derivatives and methods of use thereof

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2632603

The present invention relates to Dibenzonaphthyridine Derivatives , compositions comprising an ef fective amount of a Dibenzonaphthyridine Derivative and methods for treating or preventing a proliferative disorder, comprising administering to a subj ect in need thereof an ef f ective amount of a Dibenzonaphthyridine Derivative of formula ( I ) : or a pharmaceutically acceptable salt thereof, wherein R1 is -H, -OH, -O-C1,-C6 alkyl, -halo, -C2-C6 alkenyl, -C2-C6 alkynyl, -N(RI8)2, -NH-OR18 or-C(0)N(Rl8)2; R2 is -H, -0-C1-C6 alkyl, -halo, -C2-C6 alkenyl, -C2-C6 alkynyl, -NHR17. -N(RI7)2, -NH-OR18 or - C(O)N(RI8)2, such that when R1 is -OH or -0-C1-C6 alkyl, R2 is hydrogen; R3, R4, R5, R6, R7, R8. R9 and R10 are each independently -H, -halo, -OH, -SH, - N(RI2)2, -NHOR12, -CN, -NO2, -CF3, -OCF3, -C1-C6 alkyl, -C2-C6 alkenyl, -C2-C6 alkynyl, -C3-C8 cycloalkyl, -C3-C8 cycloalkenyl, -phenyl, -benzyl, -(CH2)n-O- C1-C6alkyl, -0-C2-C6 alkenyl, -0-C2-C6 alkynyl, -O-phenyl, -S-phenyl, -NH-C1- C6 alkyl, -(CH2)n-C(O)-R11, -(CH2)n-O)-R11, -(CH2)n-NHC(O)-R11, -S-C1-C6 alkyl, -S(O)-C1-C6 alkyl, -SO2-C1-C6 alkyl, -SO2NH-C1-C6 alkyl, -SO2NH-C2-C6 alkenyl, -SO2NH-C2-C6 alkynyl, -Y-(CH2)K-M- CH(R14)R15, -Y-(CH2)g-R16, -Y- (CH2)k-M-(CH2)p-R16, -Y-(CH2)k-(W)a-(CH2)q-Z, -Y-(CH2)P- (Z)_-(CH2)q-Z, or such that R3, R4, R5, R6, R7, R8, R9 and R10 are not simultaneously hydrogen.

La présente invention concerne des dérivés de dibenzonaphtyridine, des compositions comprenant une quantité efficace d'un dérivé de dibenzonaphtyridine et des procédés pour traiter ou prévenir un trouble prolifératif, comprenant l'administration à un sujet en ayant besoin d'une quantité efficace d'un dérivé de dibenzonaphtyridine.

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