Dibenzyl amine compounds and derivatives

Details Dibenzyl amine compounds and derivatives Dibenzyl amine compounds and derivatives

C - Chemistry, Metallurgy

07

D

C07D 257/06 (2006.01) A61K 31/41 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2589322

Dibenzyl amine compounds and derivatives, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

Cette invention concerne des composés et des dérivés de dibenzyl amine, des compositions pharmaceutiques contenant ces composés et l'utilisation de ces composés pour augmenter le taux de certains lipides plasmatiques, y compris celui du cholestérol lipoprotéine haute densité (HDL), ou pour réduire le taux de certains autres lipides plasmatiques, tel que celui du cholestérol lipoprotéine basse densité (LDL) et des triglycérides, afin de traiter des maladies qui sont exacerbées par de faibles taux de cholestérol HDL et/ou des niveaux élevés de cholestérol LDL et de triglycérides, telles que l'athérosclérose et des maladies cardiovasculaires chez certains mammifères, y compris chez les êtres humains.

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