C - Chemistry – Metallurgy – 08 – F
Patent
C - Chemistry, Metallurgy
08
F
C08F 299/00 (2006.01) A61K 48/00 (2006.01) C08F 293/00 (2006.01) C08F 299/02 (2006.01) C08F 299/04 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2724105
Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.
Copolymères et leurs procédés de fabrication et d'utilisation. De tels Copolymères comptent au moins deux blocs, soit un premier bloc comportant au moins une unité hydrophile au pH physiologique, et un second bloc comprenant des groupes hydrophobes. Le second bloc comprend au moins une unité dotée d'un groupe qui est anionique environ au pH physiologique. Les copolymères décrits ici perturbent lune membrane cellulaire, dont une membrane extracellulaire, une membrane intracellulaire, une vésicule, un organite, un endosome, un liposome, ou un globule rouge. De préférence, dans certains cas, le copolymère perturbe la membrane et pénètre dans le milieu intracellulaire. Dans des exemples spécifiques, ce copolymère est endosomolytique.
Benoit Danielle
Convertine Anthony J.
Duvall Craig L.
Gall Anna
Hoffman Allan S.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Phaserx Inc.
University Of Washington
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