Dicalcium phosphate dihydrate with improved stability and...

Details Dicalcium phosphate dihydrate with improved stability and... Dicalcium phosphate dihydrate with improved stability and...

C - Chemistry, Metallurgy

01

B

167/320.3

C01B 25/32 (2006.01) A61K 7/16 (1980.01)

Patent

CA 1135627

ABSTRACT Dicalcium phosphate dihydrate containing a sufficient amount of trimagnesium phosphate and/or tetrasodium pyrophosphate to inhibit spontaneous hydrolysis and/or decomposition of the dicalcium phosphate dihydrate is widely used as a dental polishing agent with and without added fluoride. Now it has been round that dicalcium phosphate dihydrate containing a sufficient amount of pyrophosphate to provide hydrolytic stability to the dicalcium phosphate can have improved fluoride stability when about 0.1 weight percent to about 5 weight percent of trimagnesium phosphate, and about 0.1 weight percent to about 3 weight percent of at least one pharmaceutically acceptable condensed phos- phate salt is added to the formulation In the preferred embodiment less than 2 percent sodium triphosphate provides satisfactory results.

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