A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4178 (2006.01) A61K 31/341 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2565418
Dicationic compounds that are highly selective for binding G-quadruplex DNA are described. Several compounds exhibit groove binding toward G--quadruplex DNA and in vitro and in vivo activity versus Trypanosoma brucei rhodesiense. The compounds represent novel drugs for the treatment of cancer, malaria, leishmania, and trypanosomiasis.
Boykin David W.
Ismail Mohamed A.
Kumar Arvind
Nanjunda Rupesh
Tidwell Richard R.
Georgia State University Research Foundation Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The University Of North Carolina At Chapel Hill
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