Dichloro-substituted imidazole derivatives as antifungal agents

Details Dichloro-substituted imidazole derivatives as antifungal agents Dichloro-substituted imidazole derivatives as antifungal agents

C - Chemistry, Metallurgy

07

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167/237, 260/200

C07D 233/56 (2006.01) A61K 31/415 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2014202

Dichloro-substituted 1-(5H-dibenzo[a,d]cyclohep- ten-5-yl)-1H-imidazole compounds of formula (I), in which -X- is either -CH2-CH2- or -CH=CH-, and their pharmaceutically acceptable addition salts, preferably the nitric acid ones. Products of formula (I) are prepared from products of formula (VI) where Z repre- sents a leaving group such as halogen, by treatment with an excess of imidazole in dimethylformamide. Products (I) show an antifungal activity comparable -or superior- to antimycotics in the market, such as Clo- trimazole and Bifonazole. Image Image (I) (VI)

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