Dichloroacetate in combination with cardioprotective or...

A - Human Necessities – 61 – K

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A61K 31/7048 (2006.01) A61K 31/137 (2006.01) A61K 31/138 (2006.01) A61K 31/19 (2006.01) A61K 31/554 (2006.01) A61K 31/704 (2006.01) A61K 38/16 (2006.01) A61K 38/49 (2006.01) A61K 45/06 (2006.01) A61P 9/04 (2006.01)

Patent

CA 2490636

The present invention provides compositions and methods for using cardioprotective or hemodynamic drugs in combination with dichloroacetate enabling usage of cardioprotective or hemodynamic drugs at concentrations higher than used in normal clinical practice without increasing deleterious side effects normally associated with the cardioprotective or hemodynamic drug, thereby conferring added clinical benefit. The present invention teaches administration of DCA with cardioprotective or hemodynamic drugs as an adjunct therapy thereby conferring added clinical benefit to clinically recommended protocols.

La présente invention concerne des compositions et des méthodes destinées à l'utilisation de médicaments cardioprotecteurs ou hémodynamiques en combinaison avec du dichloroacétate et permettant l'utilisation de médicaments cardioprotecteurs ou hémodynamiques en concentrations supérieures à celles utilisées dans la pratique clinique normale sans augmentation des effets secondaires indésirables habituellement associés à un médicament cardioprotecteur ou hémodynamique, d'où un avantage clinique supplémentaire. La présente invention définit l'administration de DCA avec des médicaments cardioprotecteurs ou hémodynamiques comme traitement d'appoint, d'où un avantage clinique supplémentaire par rapport aux protocoles cliniquement recommandés.

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