Dichloroaniline derivatives

Details Dichloroaniline derivatives Dichloroaniline derivatives

C - Chemistry, Metallurgy

07

C

167/179, 260/557

C07C 237/20 (2006.01) C07C 311/32 (2006.01) C07D 295/192 (2006.01)

Patent

CA 1296335

ABSTRACT DICHLOROANILINE DERIVATIVES The invention provides compounds of the general formula (I) Image ( I ) wherein X represents a bond, C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene chain and Y represents a bond, or a C1-4 alkylene, C2-4 alkenylene or C2-4 alkynylene chain with the proviso that the sum total of carbon atoms in X and Y is not more than 8; Ar represents a phenyl group substituted by one or more substituents selected from nitro, -(CH2)qR [where R is C1-3 alkoxy, -NR3R4 (where R3 and R4 each represent a hydrogen atom, or a C1-4 alkyl group, or -NR3R4 forms a saturated heterocyclic amino group which has 5-7 ring members and optionally contains in the ring one or more atoms selected from -O- or -S- or a group -NH- or N(CH3)-), -NR5COR6 (where R5 represents a hydrogen atom or a C1-4 alkyl group, and R6 represents a hydrogen atom or a C1-4 alkyl, C1-4 alkoxy or -NR3R4 group), and q represents an integer from 1 to 3], -(CH2)rR7 [where R7 represents -NR5SO2R8 (where R8 epresents a C1-4 alkyl, phenyl or -NR3R4 group) -NR5COCH2N(R5)2 (where each of the groups R5 represents a hydrogen atom or a C1-4 alkyl group), -COR9 (where R represents hydroxy, C1-4 alkoxy or NR3R4), -SR10 (where R10 is a hydrogen atom, or a C1-4 alkyl group optionally substituted by hydroxy, C1-4 alkoxy or NR3R4), -SOR10, -SO2R10, -CN or -NR11R12 (where R11 and R12 represent a hydrogen atom or a C1-4 alkyl group, at least one of which is C2-4 alkyl substituted by a hydroxy, C1-4 alkoxy or NR3R4 group), and r represents an integer from 0 to 3], -O(CH2)qCOR9 (where q and R9 are as defined above), or -O(CH2)tR13 [where R13 represents hydroxy, NR3R4, NR11R12 or a C1-4alkoxy group optionally substituted by hydroxy, C1-4 alkoxy or NR3R4, and t is an integer 2 or 3]. R1 and R2 each represents a hydrogen atom or a C1-3 alkyl group, with the proviso that the sum total of carbon atoms in R1 and R2 is not more than 4; and physiologically acceptable salts and solvates (e.g. hydrates) thereof. The compounds have a stimulant action at .beta.2-adreno-receptors and may be used in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.

520447

Affiliated with

Also associated with

Rating

Dichloroaniline derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dichloroaniline derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dichloroaniline derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1318732