Differences in intestinal gene expression profiles

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2573090

The invention provides a set of genes or gene sequences comprising at least 2 genes and the use of said set of genes or gene sequences for the determination of intestinal health, and/or disease of an animal or a human. The invention further provides methods to detect the presence or absence of an intestinal disease in an animal or a human comprising measuring, in a sample of said animal or human, expression levels of a set of genes or gene sequences according to the invention, or a gene specific fragment of said genes and comparing said expression levels with a reference value such as the expression levels of said set of genes in a sample of intestinal tissue of an healthy animal or human.

L'invention porte sur un ensemble de gènes ou de séquences géniques comprenant au moins deux gènes et sur l'utilisation dudit ensemble de gènes ou de séquences géniques pour déterminer l'état de santé et/ou de maladie intestinale chez un animal ou un humain.L'invention concerne en outre des procédés qui permettent de détecter la présence ou l'absence d'une maladie intestinale chez un animal ou un humain, qui consistent à mesurer, dans un prélèvement de l'animal ou de l'humain, les niveaux d'expression d'un ensemble de gènes ou de séquences géniques selon l'invention, ou d'un fragment spécifique de gène desdits gènes, et à comparer les niveaux d'expression à une valeur de référence, telle que les niveaux d'expression dudit ensemble de gènes dans un prélèvement de tissus intestinaux d'un animal ou d'un humain en bonne santé.

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