Differential drug release from a medical device

Details Differential drug release from a medical device Differential drug release from a medical device

A - Human Necessities

61

L

A61L 31/10 (2006.01) A61L 31/02 (2006.01) A61L 31/04 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2678611

The invention relates to a medical device, such as an intravascular stent, useful for delivering two or more therapeutic agents to a body tissue of a patient at different rates, and methods for making and using such medical device. The medical device includes a substrate and/or coating having a plurality of pores, dispersed in said pores are a plurality of a first and a second therapeutic agents, wherein said first therapeutic agent is bonded to one or more molecule(s) of a first material and the second therapeutic agent bonded to one or more molecule(s) of a second material, such that when the medical device, is in use (e.g., implanted into a body lumen such as a blood vessel), bonded first therapeutic agent is released from the medical device at a rate that is slower than the rate at which the bonded second therapeutic agent is released from the medical device.

L'invention concerne un dispositif médical, par exemple un stent intravasculaire, utilisé pour distribuer deux ou plusieurs agents thérapeutiques à un tissu corporel d'un patient à différents débits, ainsi que des procédés de fabrication et d'utilisation d'un tel dispositif médical. Le dispositif médical comprend un substrat et/ou un revêtement présentant une pluralité de pores dans lesquels sont dispersés un premier et un second agent thérapeutique. Le premier agent thérapeutique est lié à une ou plusieurs molécules d'une première matière et le second agent thérapeutique est lié à une ou plusieurs molécules d'une seconde matière, de manière que lorsque le dispositif médical est utilisé (par exemple implanté dans une lumière corporelle telle qu'un vaisseau sanguin), le premier agent thérapeutique lié est libéré du dispositif médical à un débit inférieur au débit auquel le second agent thérapeutique lié est libéré du dispositif médical.

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