C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/7105 (2006.01) A61P 9/00 (2006.01) C12N 15/113 (2010.01) C40B 30/04 (2006.01) C40B 40/06 (2006.01)
Patent
CA 2693031
The present invention discloses specific miRNAs as novel biomarkers and therapeutic targets in the treatment of heart failure. Methods of treating or preventing heart failure in a subject by administering mimics or inhibitors of these particular miRNAs are disclosed. A method of diagnosing or prognosing heart failure in a subject by determining the level of expression of one or more miRNAs is also described.
La présente invention concerne des miARN spécifiques en tant que biomarqueurs et cibles thérapeutiques novateurs dans le traitement d'une insuffisance cardiaque. Des procédés de traitement ou de prévention d'une insuffisance cardiaque chez un sujet par administration de substances mimétiques ou d'inhibiteurs de ces miARN particuliers sont révélés. Un procédé de diagnostic ou de pronostic d'une insuffisance cardiaque chez un sujet par détermination du taux d'expression d'un ou de plusieurs miARN est également décrit.
Bristow Michael R.
Port Jonathan David
Sucharov Carmen
Deeth Williams Wall Llp
The Regents Of The University Colorado
LandOfFree
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